Case Studies - OSTA Biomaterials

Clinical Evidence in Practice

Explore real-world clinical applications of OSTA Biomaterials in bone regeneration and implant dentistry. Our case studies document the use of OSTA regenerative biomaterials across a range of surgical procedures, highlighting clinical handling, bone integration, radiographic outcomes and long-term treatment results. Each case demonstrates how evidence-based biomaterials can support predictable regenerative outcomes and provide a stable foundation for successful implant rehabilitation.

Socket Preservation with OSTA Maxigro™: Six-Month Histological Outcome

This clinical case study documents socket preservation using OSTA Maxigro™, following the treatment from tooth extraction and graft placement through membrane coverage, suturing and a six-month histological evaluation. Histological examination demonstrated new bone formation and various stages of bone maturation, with no inflammatory response reported in the case conclusion. Explore the complete clinical workflow, treatment rationale and documented outcome in the full case study.

Download Case Study: Socket Preservation October 2017

Sinus Augmentation with OSTA Maxigro™: Six-Month Histological Evaluation

This clinical case study documents sinus augmentation using OSTA Maxigro™, from surgical access and graft placement through membrane closure, six-month healing, trephine sampling and subsequent implant placement. Histological evaluation at six months demonstrated new bone formation and various stages of bone maturation, with no serious inflammatory response reported in the case conclusion. The full case study provides a detailed visual overview of the surgical workflow, healing assessment and clinical outcome.

Download Case Study: Sinus Lift October 2019

Bilateral Sinus Lift with Immediate Implant Placement Using OSTA Maxigro™

This clinical case study documents a bilateral sinus lift with immediate implant placement using OSTA Maxigro™ and PRF barriers. Following a five-month healing and integration period, the clinical review reported very good bone formation around all implant surfaces, very good keratinized gingiva and an uneventful treatment progression. Explore the complete surgical workflow, graft preparation, implant placement, CBCT review and clinical outcome in the full case study.

Download Case Study: Immediate Placement January 2023

FAQs

What is OSTA Maxigro™?

OSTA Maxigro™ is a high-surface-area cancellous bovine xenograft bone graft material designed to support new bone formation. Its interconnected porous and osteoconductive structure provides a scaffold for biological activity, cellular attachment, vascular infiltration and bone regeneration.

What clinical applications are demonstrated in the OSTA Maxigro™ case studies?

The clinical case studies demonstrate the use of OSTA Maxigro™ in socket preservation, sinus augmentation and bilateral sinus lift procedures with immediate implant placement. Together, the cases document graft preparation and placement, membrane or PRF barrier use, healing, histological evaluation and subsequent or simultaneous implant placement.

What did the socket preservation case study show?

The socket preservation case evaluated OSTA Maxigro™ following extraction, graft placement, membrane coverage and suturing. At six months, histological evaluation demonstrated new bone and various stages of bone maturation and formation within the augmented socket, with no inflammatory response noted in the case conclusion.

What were the findings of the sinus lift case study?

In the sinus augmentation case, OSTA Maxigro™ was used to create graft volume before later implant placement. The site was evaluated after six months using trephine sampling and histological examination. New bone was observed, with the grafted sinus showing various stages of bone maturation and formation.

Can OSTA Maxigro™ be used with immediate implant placement?

One of the documented clinical cases involved bilateral sinus lifts with immediate implant placement using OSTA Maxigro™ together with PRF barrier support. After a five-month integration period, the case reported very good bone formation around the implant surfaces and very good keratinized gingiva around the implants.

How long were the grafted sites allowed to heal?

Healing periods varied according to the clinical procedure. The socket preservation and staged sinus augmentation cases included six-month evaluations, while the bilateral sinus lift with immediate implant placement case included a five-month implant integration period.

Is there histological evidence of new bone formation with OSTA Maxigro™?

Yes. Histological examination in the socket preservation case demonstrated new bone six months after augmentation, with different stages of bone maturation and formation. The sinus augmentation case also documented new bone at six months. In addition, OSTA's clinical evidence describes human trephine specimens showing new mineralized bone associated with OSTA Maxigro™ particles.

Why is the high surface area of OSTA Maxigro™ important?

Bone regeneration begins at the graft surface. A high surface area provides increased interface for blood proteins and cells to interact with the graft. OSTA describes a biological sequence involving protein adsorption, osteogenic cell attachment and proliferation, vascular infiltration, new bone formation and subsequent bone remodeling.

Were membranes or biological preparations used in the case studies?

Yes, although the surgical protocol differed between cases. The socket preservation case included membrane coverage and suturing. The staged sinus augmentation case included membrane placement over the augmented site. The bilateral immediate-placement case used PRF barrier support, with PRP also used during graft preparation.

What particle sizes of OSTA Maxigro™ are available?

OSTA Maxigro™ is available in two particle-size ranges. The S Range (300 µm–1 mm) is intended for applications where adaptability and high internal surface area are important, including ridge preservation and sinus-lift procedures. The L Range (1–2 mm) provides greater space maintenance for larger defects, sinus augmentation and structural grafting applications.

What is the role of OSTA Maxigro™ during bone regeneration?

OSTA Maxigro™ acts as an osteoconductive scaffold within the grafted site. Its porous structure provides an environment for cellular attachment and vascular infiltration while new bone forms and remodels through the healing process. OSTA's clinical information illustrates progression from early healing and integration through active bone formation, mineralization and remodeling.

Do these case studies guarantee the same clinical outcome in every patient?

No. These are individual clinical case studies documenting specific patients, surgical procedures and follow-up periods. Clinical outcomes can vary according to the patient, defect anatomy, surgical technique, healing conditions and treatment plan. The case studies should therefore be considered together with the product Instructions for Use, available scientific evidence and the clinician's professional judgement.